The ORKAD team aims to exploit simultaneously expertise in combinatorial optimization and knowledge extraction to address upcoming optimization problems. While the two scientific areas are developed more or less independently, the synergy between combinatorial optimization and knowledge extraction offers an opportunity first, to improve the performance and autonomy of optimization methods thanks to Knowledge and secondly to solve efficiently Knowledge extraction problems thanks to operational research methods. Our approaches are mainly based on mono and multi-objective combinatorial optimization and led to the development of open source software.