In this cross-disciplinary area, we design various digital tools (machine learning, optimisation, formal methods, simulations, modelling of biological systems and flexible and robotic devices, geometric and bio-mechanical modelling of anatomical struc- tures, bioinformatics methods) for the analysis, modelling and simulation of data from living organisms, including hetero- geneous data, omics, imaging and video. This research has ap- plications in ecology (evolution of species, role of interactions between molecules/individuals/species, etc.) and health (patient monitoring, prediction and diagnosis of pathologies, modelling of biological processes, simulation of surgical operations, etc.).